The “male pair-bonding” gene is a genetic variant of the AVPR1A gene. AVPR1Avariation can occur in the regulatory region of the gene at three different repetitive sequences, known as RS1, RS3 and GT25. A specific version of RS3, known as the RS3 334 allele, is associated with diminished pair-bonding in males.
Men with the RS3 334 allele are less likely to form a strong bond with their partners and are more likely to experience marital crisis or divorce. They are less likely to get married and more likely to cohabitate, than individuals without the RS3 334 allele. Spouses of men with the RS3 334 allele report feeling less affection and consensus in the marriage.
Although there is no evidence that this variant influences sexual behavior in females, there are different AVPR1A variations, which are associated with an increased likelihood of infidelity in females. These variants are detected in the Female Infidelity Gene AVPR1A Test.
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